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KMID : 0525720190240040227
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Journal of Chitin and Chitosan
2019 Volume.24 No. 4 p.227 ~ p.233
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Implantation of Chitosan Coated Titanium Plate on Bone Formation in Rat Calvaria
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Cho Seung-Whan
Lim Won-Bong
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Abstract
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In order to improve the success of internal fixation in hip fracture, various treatments were applied to titanium surface in plate. Although there have been a lot of trial to handle the surface of titanium with various material so that the bone and the plate could be tightly combined, they have still failed to maintain the osteoinctivities in the past. Therefore, the purpose of this study is to investigate the possibility of improvement the osteoinctivity when the surface of titanium plate was coated with chitosan, and confirmed that the coated material stayed on. Using the calvarial defect model in rats, the study on the bone regeneration of the chitosan coated titanium plate was carried out. The chitosan coating led a rough surface on the titanium plate and fit bone formation between titanium plate and defected bone when the plate were implanted in the rat’s calvaria. In addition, the implantation of chitosan coated titanium plate led the new bone formation in the defected rat’s calvaria, significantly. In conclusion, the chitosan coated titanium plate developed in this study led the fit bone formation between titanium plated and defected bone by increased osteoinductivity, and it shows possibilities for clinical use in hip fracture.
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KEYWORD
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Femur, Hip fracture, Titanium alloy, Chitosan coating, Bone regeneration
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